- Choi, W., Miyamura, Y., Wolber, R., Smuda, C., Reinhold, W., Liu, H., Kolbe, L., & Hearing, V. J. (2010). Regulation of Human Skin Pigmentation in situ by Repetitive UV Exposure: Molecular Characterization of Responses to UVA and/or UVB.
- Journal of Investigative Dermatology, 130(6), 1685–1696.
- https://doi.org/10.1038/jid.2010.5
- Brenner, M., & Hearing, V. J. (2008). The protective role of melanin against UV damage in human skin.
- Photochemistry and Photobiology, 84(3), 539–549.
- https://doi.org/10.1111/j.1751-1097.2007.00226.x
- Coelho, S. G., Choi, W., Brenner, M., Miyamura, Y., Yamaguchi, Y., Wolber, R., Smuda, C., Batzer, J., Kolbe, L., Ito, S., Wakamatsu, K., Zmudzka, B. Z., Beer, J. Z., Miller, S. A., & Hearing, V. J. (2009). Short- and Long-Term Effects of UV Radiation on the Pigmentation of Human Skin.
- Journal of Investigative Dermatology Symposium Proceedings, 14(1), 32–35.
- https://doi.org/10.1038/jidsymp.2009.10
- Hönigsmann, H., Schuler, G., Aberer, W., Romani, N., & Wolff, K. (1986). Immediate Pigment Darkening Phenomenon: A Reevaluation of Its Mechanisms.
- Journal of Investigative Dermatology, 87(2), 194–197.
- https://doi.org/10.1111/1523-1747.ep12456326
- Routaboul, C., Denis, A., Vinche, A. (1999). Immediate pigment darkening: description, kinetic and biological function.
- European Journal of Dermatology, 9(2), 95-99.
- https://pubmed.ncbi.nlm.nih.gov/10066954
- Wenczl, E., et al. (1998). (Pheo)melanin photosensitizes UVA-induced DNA damage in cultured human melanocytes.
- Journal of Investigative Dermatology, 111(4), 678–682.
- https://www.sciencedirect.com/science/article/pii/S0022202X15402453
- Wolber, R., Schlenz, K., Wakamatsu, K., Smuda, C., Nakanishi, Y., Hearing, V. J., & Ito, S. (2008). Pigmentation Effects of Solar-Simulated Radiation as Compared with UVA and UVB Radiation.
- Pigment Cell & Melanoma Research, 21(4), 487–491.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC2593890
- Tadokoro, T., Yamaguchi, Y., Batzer, J., Coelho, S. G., Zmudzka, B. Z., Miller, S. A., Wolber, R., Beer, J. Z., & Hearing, V. J. (2005). Mechanisms of Skin Tanning in Different Racial/Ethnic Groups in Response to Ultraviolet Radiation.
- Journal of Investigative Dermatology, 124(6), 1326–1332.
- https://doi.org/10.1111/j.0022-202X.2005.23760.x
- Rees, J. L. (2004). The genetics of sun sensitivity in humans.
- American Journal of Human Genetics, 75(5), 739–751.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC1182105
- Brash, D. E. (2015). UV signature mutations.
- Photochemistry and Photobiology, 91(1), 15–26.
- https://onlinelibrary.wiley.com/doi/10.1111/php.12377
- Coelho, S. G., Zhou, Y., Bushar, H. F., Miller, S. A., Zmudzka, B. Z., Hearing, V. J., & Beer, J. Z. (2009). Long-Lasting Pigmentation (LLP) of Human Skin: A New Look at an Overlooked Response to UV.
- Pigment Cell & Melanoma Research, 22(4), 418–429,
- https://pmc.ncbi.nlm.nih.gov/articles/PMC2709973
- National Institutes of Health (NIH). Sun and Skin
- Parrish, J. A., Jaenicke, K. F., & Anderson, R. R. (1982). Erythema and melanogenesis action spectra of normal human skin.
- Photochemistry and Photobiology, 36(2), 187–191.
- https://pubmed.ncbi.nlm.nih.gov/7122713
- Ravnbak, M. H., Philipsen, P. A., & Wulf, H. C. (2010). The minimal melanogenesis dose/minimal erythema dose ratio declines with increasing skin pigmentation using solar simulator and narrowband ultraviolet B exposure.
- Photodermatology, Photoimmunology & Photomedicine, 26(3), 133–137.
- https://doi.org/10.1111/j.1600-0781.2010.00508.x
- Fitzpatrick, T. B. (1988). The validity and practicality of sun-reactive skin types I through VI.
- Archives of Dermatology, 124(6), 869–871.
- https://doi.org/10.1001/archderm.124.6.869
- Norval, M., & Halliday, G. M. (2011). The consequences of UV-induced immunosuppression for human health.
- Photochemical & Photobiological Sciences, 10, 199–210.
- https://pubmed.ncbi.nlm.nih.gov/21749399
- EPA (United States Environmental Protection Agency). Learn About the UV Index.
- Saadé, N. E., Nasr, I. W., Massaad, C. A., Safieh-Garabedian, B., Jabbur, S. J., & Kanaan, S. A. (2002). Modulation of ultraviolet-induced hyperalgesia and cytokine upregulation by interleukins 10 and 13.
- Pain, 96(1–2), 273–285.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC1572458
- Bernerd, F., Passeron, T., Castiel, I., & Marionnet, C. (2022). The damaging effects of long UVA (UVA1) rays: A major challenge to preserve skin health and integrity.
- International Journal of Molecular Sciences, 23(15), 8243.
- https://doi.org/10.3390/ijms23158243
- Kabashima, K., Nagamachi, M., Honda, T., Nishigori, C., Miyachi, Y., Tokura, Y., & Narumiya, S. (2007). Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptors.
- Laboratory Investigation, 87(1), 49–55.
- https://doi.org/10.1038/labinvest.3700491
- Milner, S. M. (2024). Case Q&A: Sunburn.
- ePlasty, 24, QA17. ISSN 1937-5719.
- https://www.hmpgloballearningnetwork.com/site/eplasty/case-qa/sunburn
- Trip, L. J., & Smith, M. A. (2022). Drug-induced photosensitivity: Clinical types of phototoxicity and photoallergy and pathogenetic mechanisms.
- Frontiers in Allergy.
- https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2022.876695/full
- Ciccarese, G., Drago, F., & Rebora, A. (2022). Culprit drugs, potential mechanisms and clinical consequences of drug-induced photosensitivity.
- Journal of Dermatological Science.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7898394
- StatPearls (2024). Photosensitivity.
- NCBI Bookshelf.
- https://www.ncbi.nlm.nih.gov/books/NBK431072
- U.S. Food & Drug Administration (2019). The Sun and Your Medicine.
- FDA Special Features.
- https://www.fda.gov/drugs/special-features/sun-and-your-medicine
- DrugBank (2025). Drugs causing inadvertent photosensitivity.
- DrugBank Online.
- https://go.drugbank.com/categories/DBCAT005161
- Falls Commercial, C. (2025, August 27). 7 Skincare Products That Cause Sun Sensitivity.
- Food and Drug Administration (FDA). Sunscreen: How to Help Protect Your Skin from the Sun.
- Scientific Committee on Consumer Safety (SCCS). UV Filters. Final Opinions
- Matta, M. K., Zusterzeel, R., Pilli, N. R., Patel, V., Volpe, D. A., Florian, J., Oh, L., Bashaw, E., Zineh, I., & Sanabria, C. (2019). Effect of sunscreen application under maximal use conditions on plasma concentration of sunscreen active ingredients: A randomized clinical trial.
- Journal of the American Medical Association (JAMA), 321(21), 2082–2091.
- https://jamanetwork.com/journals/jama/fullarticle/2733085
- Environmental Working Group (EWG). (2024). About the sunscreens.
- National Oceanic and Atmospheric Administration (NOAA). (2024). Skincare Chemicals and Coral Reefs.
- Wikipedia contributors. (2024). Sunscreen.
- Suh, H.‐W., Lewis, J., Fong, L., Ramseier, J. Y., Carlson, K., Peng, Z.‐H., Yin, E. S., Saltzman, W. M., & Girardi, M. (2019). Biodegradable bioadhesive nanoparticle incorporation of broad‐spectrum organic sunscreen agents.
- Frontiers in Pharmacology, 10, 1128.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6336670
- World Health Organization. (2002). Global Solar UV Index: A Practical Guide.
- https://apps.who.int/iris/handle/10665/42459
- American Academy of Dermatology (AAD). (2023). Sunscreen FAQs.
- Florida Cancer Specialists & Research Institute. UV Truth.
- Skin Cancer Foundation. Sun-Protective Clothing.
- Wikipedia contributors. (2024). Tanning.
- Owji, S., Teklehaimanot, F., Maghfour, J., & Lim, H. W. (2023). Properties and safety of topical dihydroxyacetone in sunless tanning products: A review.
- Photo-dermatology, -immunology & -medicine, 39(6), 567–572.
- https://doi.org/10.1111/phpp.12913
- Garone, M., Howard, J., & Fabrikant, J. (2015). A review of common tanning methods.
- Journal of Clinical and Aesthetic Dermatology, 8(2), 43–47.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4345932
- Kongshoj, B., Mikkelsen, N. D., Kobayasi, T., Lerche, C. M., & Wulf, H. C. (2007). Ammonium chloride and L-tyrosine enhance melanogenesis in vitro but not in vivo even in combination with ultraviolet radiation.
- Photo-dermatology, -immunology & -medicine, 23(5), 197–202.
- https://doi.org/10.1111/j.1600-0781.2007.00307.x
- Slominski, A., Zmijewski, M., & Pawelek, J. (2012). L-tyrosine and L-DOPA as hormone-like regulators of melanocyte functions.
- Pigment Cell & Melanoma Research, 25(1), 14–27.
- https://doi.org/10.1111/j.1755-148X.2011.00898.x
- Herrmann, J. L., Cunningham, R., Cantor, A., Elewski, B. E., & Elmets, C. A. (2014). Tanning accelerators: prevalence, predictors of use, and adverse effects.
- J Am Acad Dermatol, 71(6), 1174–1179.
- https://pubmed.ncbi.nlm.nih.gov/25458018
- Yamaguchi, Y., & Hearing, V. J. (2009). Physiological factors that regulate skin pigmentation.
- Biofactors, 35(2), 193–199.
- https://pubmed.ncbi.nlm.nih.gov/19449448
- Alikhan, A., Felsten, L. M., Daly, M., & Petronic-Rosic, V. (2009). Vitiligo: A comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up.
- J Am Acad Dermatol, 65(3), 473–491.
- https://pubmed.ncbi.nlm.nih.gov/21839315
- Kasper Fjellhaugen Hjuler, Henrik Frank Lorentzen (2014). Melanoma associated with the use of melanotan-II
- Department of Dermatology.
- https://doi.org/10.1159/000356389
- FDA. (2022). Tanning pills.
- StatPearls. 2024. Miliaria – StatPearls.
- A.K.C. Leung et al., PMC. 2022. Tinea versicolor: an updated review.
- Medscape. Miliaria (Heat Rash).
- S. Plensdorf et al., American Family Physician, 2017. Pigmentation Disorders: Diagnosis and Management.
- Bikle, D. D. (2021). Vitamin D: Production, Metabolism, and Mechanism of Action.
- Holick, M. F. (1995). Environmental factors that influence the cutaneous production of vitamin D₃.
- American Journal of Clinical Nutrition, 61(3 Suppl), 638S–645S
- https://doi.org/10.1093/ajcn/61.3.638S
- Booth, D. R., et al. (2016). Cistromic and genetic evidence that VDR regulates thousands of genomic sites.
- Frontiers in Immunology, 7, 238.
- https://pubmed.ncbi.nlm.nih.gov/26986782
- Dowdy, J. C., et al. (2010). Holick’s rule and vitamin D from sunlight.
- Medical Hypotheses, 74(1), 106–108.
- https://doi.org/10.1016/j.jsbmb.2010.04.002
- Heaney, R. P., et al. (2009). Vitamin D₃ distribution and status in the body.
- Journal of the American College of Nutrition, 28(3), 252–256,
- https://pubmed.ncbi.nlm.nih.gov/20150598
- Chandler, P. D., et al. (2020). Effect of vitamin D₃ supplements on development of advanced cancer: A secondary analysis of the VITAL RCT.
- JAMA Network Open, 3(11), e2025850.
- https://doi.org/10.1001/jamanetworkopen.2020.25850
- Moan, J., et al. (2008). Addressing the health benefits and risks of increased sun exposure.
- PNAS, 105(2), 668–673.
- https://doi.org/10.1073/pnas.0710615105
- Wen, Y., Zhang, J., & Li, X. (2020). The relevance of daylight for humans.
◦ Biochimica et Biophysica Acta (BBA)
- Molecular Basis of Disease, 1866(9), 165954.
- https://doi.org/10.1016/j.bbadis.2020.165954
- Lambert, G. W., Reid, C., Kaye, D. M., Jennings, G. L., & Esler, M. D. (2002). Effect of sunlight and season on serotonin turnover in the brain.
- The Lancet, 360(9348), 1840–1842.
- https://doi.org/10.1016/S0140-6736(02)11737-5
- Chellappa, S. L., et al. (2019). Effects of light on human circadian rhythms, sleep and mood.
- Somnologie, 23(3), 147–156.
- https://doi.org/10.1007/s11818-019-00218-x
- Liu, D., Fernandez B.O., Hamilton, A., et al. (2014). UVA irradiation of human skin vasodilates arterial vasculature and lowers blood pressure independently of nitric oxide synthase.
- Journal of Investigative Dermatology, 134(7), 1839–1846.
- https://doi.org/10.1038/jid.2014.27
- Ahuja, S., & Kumar, P. (2022). Phototherapy in dermatological maladies (Review).
- Experimental and Therapeutic Medicine, 23(2), 136.
- https://doi.org/10.3892/etm.2021.11063
- Koullouros, E., et al. (2021). Phototherapy.
- StatPearls Publishing, Treasure Island (FL).
- https://www.ncbi.nlm.nih.gov/books/NBK563140
- American Heart Association News. (2020, Feb 28). Could sunshine lower blood pressure? Study offers enlightenment.
- Narayanan, D. L., Saladi, R. N., & Fox, J. L. (2010). Mechanisms of ultraviolet (UV)-induced skin cancer.
- Photochemical & Photobiological Sciences, 9(2), 250–268.
- https://doi.org/10.1039/b9pp00388d
- Ananthaswamy, H. N., & Pierzchalski, K. (2014). Ultraviolet radiation in DNA damage and repair involving DNA photolyase and nucleotide excision repair mechanisms.
- Mutagenesis, 29(6), 477–491.
- https://doi.org/10.1093/mutage/geu027
- Yaar, M., & Gilchrest, B. A. (2007). Photoaging: mechanism, prevention & therapy.
- British Journal of Dermatology, 157(suppl 2), 54–58.
- https://doi.org/10.1111/j.1365-2133.2007.07747.x
- Roberts, J. E. (2011). Ultraviolet radiation as a risk factor for cataract and macular degeneration: a review.
- Survey of Ophthalmology, 56(1), 2–9.
- https://doi.org/10.1016/j.survophthal.2010.07.003
- Katiyar, S. K. (2007). UV‐induced immune suppression and photocarcinogenesis.
- Photodermatology, Photoimmunology & Photomedicine, 23(2–3), 119–126.
- https://doi.org/10.1111/j.1600-0781.2007.00304.x
- American Academy of Dermatology. (n.d.). Indoor tanning: Risks and facts.
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